Object
Title: Prehospital abciximab administration in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
Abstract:
Early abciximab administration before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is believed to improve outcome. However, the evidence supporting abciximab use before and during transfer for PPCI is limited. Aim: To assess safety and the effect of early abciximab administration in patients (pts) with first anterior wall STEMI. Methods: A total of 59 non-shock pts with STEMI <12h admitted to remote hospitals with anticipated delay to PPCI < 90 min were randomly assigned to two study groups – 27 pts received abciximab before transfer to cath lab (early=group EA) and 32 pts in cath lab immediately before PPCI (late=group LA). Results: Better infarct-related artery patency before PPCI and better ST-segment resolution 60 min after PPCI was found in EA group. There was a significant difference in 30-day left ventricular end-systolic volume index-ESVI and end-diastolic volume index-EDVI and a trend in ejection fraction-EF in echocardiography favoring EA group. In cardiac magnetic resonance sub-study lower ESVI, EDVI and higher EF was found in EA group after 1 year. A trend towards lower delayed enhancement infarct size was also observed in EA group. Similar rate of bleeding complications and major adverse events was found in both groups. Conclusions: Early abciximab administration before transfer for PPCI in patients with f ; irst anterior wall STEMI is feasible and results in more frequent infarct-related artery patency before PPCI, better myocardial tissue perfusion after PPCI and improved left ventricular function during 30-day and 1-year follow up.
Place of publishing:
Level of degree:
Degree discipline:
Degree grantor:
Promoter:
Date issued:
Identifier:
Call number:
Language:
Access rights:
Object collections:
Last modified:
Jul 20, 2022
In our library since:
Nov 21, 2012
Number of object content hits:
320
Number of object content views in PDF format
0
All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/974
Show description in RDF format:
Show description in OAI-PMH format:
| Edition name | Date |
|---|---|
| ZB-107306 | Jul 20, 2022 |
Objects
Similar
Rakowski, Tomasz
Tomala, Marek
Siudak, Zbigniew
Brzeziński, Michał
Żygadło, Agnieszka
Gąsior,Mariusz (oprac ).
The influence of hyperglycemia on myocardial reperfusion in myocardial infarction treated invasively
Giszterowicz, Dawid.
Depukat, Rafał.
