Title:

Carotid atherosclerosis versus plasma levels of an endogenous nitric oxide synthesis inhibitor in rheumatoid arthritis

Author:

Włoch, Alicja

Subject:

atherosclerosis ; nitric oxide ; endothelial progenitor cells ; rheumatoid arthritis ; ultrasonography of carotid arteries

Abstract:

Our aim was to validate the hypothesis that indices of early atherosclerosis and blood count of endothelial progenitor cells may be linked to abnormal plasma levels of an endogenous inhibitor of nitric oxide synthesis, asymmetric NG,NG-dimethyl-L-arginine (ADMA) in rheumatoid arthritis (RA). The results suggest that: 1. Plasma levels of ADMA are elevated in RA patients without cardiovascular disease or traditional risk factors. 2. The degree of EPC depletion in blood of RA patients is parallel to the magnitude of excessive ADMA accumulation. 3. In RA blood EPC depletion and elevated plasma ADMA/L-arginine ratio are independently related to carotid intima-media complex thickness, an index of early atherosclerosis. These abnormalities are also associated with the presence of carotid plaques in RA patients. 4. The imbalance between the substrate (L-arginine) and endogenous inhibitor of nitric oxide synthesis (ADMA) may contribute to accelerated atherogenesis in RA, which can partially be due to impaired mobilization of EPC from the bone marrow, a nitric oxide-dependent process.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby narządów ruchu ; choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Andrzej Surdacki

Date:

2007

Date issued:

2007

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-106433

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum