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Title: An asymptomatic heart dysfunction of ischemic etiology : echocardiografic parameters and the level of amino terminal fragment B-type natriuretic peptide (NT-proBNP).


In the investigation was analised the group of patients with stable angina pectoris, without any signs and symptoms of chronic heart failure of the left ventricle (LV). The clinical statement, echocardiographic systolic and diastolic parameters and spiroergometric parameters and also NT-proBNP and hsCRP were analised. Patients were divided into 3 groups: A-with normal LV function, B-with the diastolic dysfunction of LV and C- with both: systolic and diastolic dysfunction. The patients were examined twice during two years observation. It was established that about half of the group A had a risk of the LV diastolic dysfunction during 2 years. In 25% patients with impaired relaxation was observed progression of the LV diastolic dysfunction in 2 years. But nearly 6% developed also systolic dysfunction of the LV. Diabetes type 2 predisposed to progression of diastolic abnormalisties of LV during 2 years. Severity of diastolic dysfunction increased with higher level of NT-proBNP. In patients VO2peak and VE/CO2 depended on filling profile of the LV and also of systolic function. AT was significantly depended on LV filling pattern. In patients of A group decreased value of VO2peak predisposed to development of LV diastolic dysfunction. In patients with LV diastolic dysfunction and VO2peak ≤18,4 ml/kg/min was observed progression of LV diastolic dysfunction during two years. - In patients with stable angina pectoris after 2 years observation, echocardiographic parameters: E/E’2 ≥8 and E/Vp2 ≥1,5 were connected with progression of diastolic dysfunction of the left ventricle.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski


Wiesława Piwowarska

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Sep 17, 2019

In our library since:

Nov 21, 2012

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Edition name Date
ZB-110929 Sep 17, 2019


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