Advanced search ?

Object

Download

Title: Factors affecting elimination and clinical tolerance of high doses of methotrexate, administered as remission consolidation therapy in children with acute lymphoblastic leukemia

Author:

Ćwiklińska, Magdalena

Date:

2009

Type:

Praca doktorska

Abstract:

This study included 852 chemotherapy cycles with methotexate (Mtx), administered in the dose of 2 g/m2 and 3 g/m2 to 218 children with acute lymphoblastic leukemia. Prolonged Mtx elimination was observed in about 17% of cycles and 45% of patients. Major factors that affected Mtx elimination included: higer steady-state Mtx levels and impairment of drug clearance in the early phase of its rapid elimination. Considerable variability of Mtx pharmacokinetics, demonstrated in the study, is an argument for adapting the dose to a current, variable clearance of the drug in a given patient. In general tolerance of high doses of Mtx was good and was not associated with intensified (grade 3 and 4) or prolonged toxicities. The most common early complications were: hepatic dysfunction, nausea and vomiting and oral mucositis. The most significant factor affecting the intensity of early toxicity was prolonged exposure to cytotoxic concentrations of Mtx. The high risk group for intensified early toxicities of high doses Mtx therapy includes: patients with higher serum steady-state drug levels, characterized by slower drug elimination and lower coefficient of elimination in the early phase of drug excretion, children above 10 years of life and patients during the first chemotherapy cycle with Mtx.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia ; farmakologia

Degree grantor:

Uniwersytet Jagielloński – Collegium Medicum

Promoter:

Balwierz, Walentyna

Date issued:

2009

Identifier:

oai:dl.cm-uj.krakow.pl:937

Call number:

ZB-110922

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

acute lymphoblastic leukemia high doses of methotrexate monitored therapy early toxicities children

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

743

Number of object content views in PDF format

175

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/937

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-110922 Jun 26, 2023

Objects

Similar

Factors affecting elimination and clinical tolerance of high doses of methotrexate, administered as remission consolidation therapy in children with acute lymphoblastic leukemia

Ćwiklińska, Magdalena

2009
Praca doktorska

Detection of minimal residual disease in children with acute lymphoblastic leukemia treated according to the ALL IC-BFM-2002 Protocol

Pawińska-Wąsikowska, Katarzyna

2009
Praca doktorska

Acute lymphoblastic leukemia in children in XXI century

Kwiecińska, Kinga

2023
Praca doktorska

The risk of childhood acute lymphoblastic leukemia development related with selected genetic polymorphisms in Polish population

Madetko-Talowska, Anna

2009
Praca doktorska

Wybrane zagadnienia z pediatrii i opieki nad dzieckiem niepełnosprawnym

Kędra,Edyta (red nauk ). Kowalak,Czesław (współpraca)

e-książka

The evaluation of the direction and dynamics of the differences in the frequency of allergic features in children from Starachowice in 1999 in comparison to 1988

Lesiak-Bednarek, Anna

2004
Praca doktorska

Nurses' attitudes towards children with epilepsy

Zalewska-Puchała, Joanna

2005
Praca doktorska

Disordered calcium - phosphate homeostasis and nutritional status in children with newly diagnosed inflammatory bowel disease

Świat, Agnieszka

2012
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information