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impaired fasting glucose ; impaired glucose tolerance ; risk factors ; diabetes type 2 ; metabolic syndrome
Abstract:
The aim of the presented study was to assess the and to assess risk factors determining the progression to diabetes type 2. Participants invited to the study were people who in 1998-2000 during the Polish Multicenter Study of Diabetes Epidemiology were diagnosed with impaired glucose tolerance or impaired fasting glucose. In all study participants anthropometric measurements, blood pressure measurements, biochemical tests and standardized questionnaire history of actual physical condition as well as lifestyle were examined. Anthropometric measurements, biochemical data and questionnaire data were compared with data from the baseline study done in 1998-2000. The prevalence of type 2 diabetes in examined population of 264 people with previously ( 1998-2000) found impaired glucose tolerance or impaired fasting glucose was 17%. After the inclusion of data coming from the patient who fulfilled the questionnaire examination but did not personally participated in the control study diabetes was found in 288 people ( 18,41 % ). In the studied population important predictive factors of the progression to type 2 diabetes were fasting glicernia , fasting hiperinsulinernia, insulin resistance measured as HOMA IR index, WHR, and family history of type 2 diabetes. The presence of the metabolic syndrome at baseline according to the WHO and to the NCEP definitions increased the risk of progress ; ion to type 2 diabetes by 90% and 50% respectively (not reaching the statistical importance).