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inflammatory factors ; diabetic nephropathy ; albuminuria
Abstract:
DM will develop in about 30 - 40% of patients with type I and in about 15-20% of patients with type II DM leading to renal failure. Presently about 24.7% of all dialyzed patients in Poland have diabetic renal disease. Mechanisms of chronic complications of DM are still unclear. The aim of the research was to evaluate selected growth and inflammatory factors on the development of changes in kidneys and vessels in patients with diabetic renal disease in the course of DM type II. The study group consisted of 48 patients with DM type II diagnosed according to WHO criteria, in whom diabetic renal disease was found in varying stages of advancement graded by the C.E. Morgensen classification. The control group consisted of 22 patients with DM type II not having renal disease (matched according to age and sex). The main result of the study having pronounced practical implications is the finding of significant correlations between progression of diabetic renal disease and inflammatory factors. These factors were analyzed in a cross-sectional study pertaining to a group of individuals with DM and nephropathy, and later as a prospective study. In this research study - multiple regression analyses proved that eGFR value correlates with significant changes and IL-6 concentration, as well as changes in PDFG BB concentration. Increased concentrations of IL-6 and PDFG BB in blood serum were ; associated with eGFR decrease. However, no significant correlation was proven between examined factors and progression of albuminuria.