Title:

Usefulness of echocardiographic parameters in predicting response to cardiac resynchronization therapy in patients with chronic heart failure

Author:

Wiliński, Jerzy

Subject:

chronic heart failure ; cardiac resynchronization therapy

Abstract:

The aim of the study was to assess the atrioventricular, inter- and intraventricular dyssynchrony in patients before and 3 months after biventricular cardiac stimulator implantation (CRT) and to determine the usefulness of echocardiographic parameters in predicting benefit related to CRT. The study group comprised 60 consecutive patients with chronic heart failure (CHF) aged 66,3 ± 8.7 years (57 men - 95%, CHF of ischaemic background - 71.7% and 28.3% of non-ischaemic), with NYHA class III-IV despite optimized pharmacotherapy with QRS > 130 ms, left ventricular end-diastolic diameter ≥ 55 mm and left ventricular ejection fraction ≤ 35%. In the whole studied group decrease of interventricular mechanical delay index (IVMD) was observed. Intraventricular dyssynchrony assessed with septal to posterior wall motion delay (SPWMD) did not alter. Results of the study indicate that echocardiographic assessment of inter- and intraventricular dyssynchrony with colour-coded tissue Doppler imaging parameters and intraventricular dyssynchrony with strain and strain rate parameters is useful in qualification for CRT. These parameters correlate significantly with reduction of left ventricular end-systolic volume or left ventricular ejection fraction.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Danuta Czarnecka

Date:

2009

Date issued:

2009

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-110244

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum