Object

Title: The influence of preoperative radiotherapy on local and systemic recurrence in rectal cancer

Abstract:

Colorectal cancer is a frequent cancer in both sexes, representing 13% of all cancer cases. Surgery still remains the main modality in rectal cancer treatment The literature is inconclusive regarding the real value of preoperative irradiation. The aim of this study is to assess the influence of preoperative hyperfractionated radiotherapy (5x5 Gy) on local and systemic recurrence rate in patients with rectal cancer operated according to TME technique. Local recurrence occurred in 4.4% of patients after preoperative radiotherapy and in 12.4% of patients undergoing only surgical treatment (p=0.017). Both groups had similar systemic recurrence rate (7.4% vs. 10.2% respectively, p=0.403). Lower rate of systemic recurrence was observed in patients operated on 4-5 weeks after the end of irradiation (2.8% vs. 12.3% in the subgroup with shorter interval, p=0.035). Survival analysis during 3-year follow-up showed no increase in overall survival in patients with combined treatment (radiotherapy + surgery). Overall survival in this group was 80% vs. 78% in control group (p=0.847). When time interval between irradiation and operative treatment was longer (4-5 weeks) 3-year survival was 85% vs. 77% in the subgroup with short interval (p=0.379). Statistically significant increase in overall survival was observed only in patients with downstaging after radiotherapy – 95% in comparison with 78% in patients operated on without previous radiotherapy (p=0.036).

Level of degree:

2 - studia doktoranckie

Degree discipline:

chirurgia ; onkologia

Degree grantor:

Wydział Lekarski

Promoter:

Piotr Richter

Date issued:

2008

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:883

Call number:

ZB-109871

ControlNumberVIRTUA:

click here to follow the link

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Sep 4, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

1 992

Number of object content views in PDF format

1987

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/883

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-109871 Sep 4, 2019
×

Citation

Citation style:

This page uses 'cookies'. More information