Title:

Factors influencing the development of cardiac arrhythmia in patients with chronic obstructive pulmonary disease

Author:

Komnata, Krystyna

Subject:

inflammation ; hyperinflation ; arrhythmias ; COPD

Abstract:

Introduction: Systemic inflammation occurring in COPD affects the function of many organs including the cardiovascular system. Objectives: To analyze factors influencing the development of cardiac arrhythmia in patients with COPD. Material and methods: In a group of 60 stable patients with GOLD stages I-IV, without comorbidities, inflammatory markers were determined. Bodyplethismography, 6 MWD, BODE, echocardiography and 24-hour Holter monitoring were performed. Results: There was a significant correlation between Lown’s ventricular arrhythmias and concentrations of fibrinogen (p=0,015) and hsCRP (p=0,04); IL-6 concentration and nPVC(rs=0,293;p<0,05); supraventricular arrhythmias and hsCRP concentration (p=0,05) and IC% after B-agonist administration(p=0,018) ) was noted. A negative correlation between hsCRP and IC%pred. (rs =-0,29; p=0,023) and IC/TLC(rs =-0,32; p=0,014) was found. There was also a correlation between TNF-a and PaCO2 (p=0,03) and RVSP (p=0,01). Conclusion: Inflammatory process is a key pathogenic contributor to ventricular and supraventricular arrhythmias in patients with COPD. The severity of static hyperinflation is related to the development of supraventricular arrhythmias. Inflammatory process has an adverse affect on the respiratory system increasing static hyperinflation.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Majewski, Jacek

Date:

2009

Date issued:

2008

Type:

Praca doktorska

Call number:

ZB-109868

Language:

pol

Access rights:

nieograniczony