Estimation of stature in children born with intrauterine growth retardation


Jaworski, Marek


intrauterine growth retardation (IUGR) ; short stature ; catch-up growth


In the world medical literature there are significant discrepancies concerning the percentage of children born with intrauterine growth retardation (IUGR), and also the percentage of children with short stature [below (-2) SDS] during preadolescence, and adolescence. In Polish literature there are no data referring to this topic. Short stature children exhibit low self-esteem, worse grades at school, and often also feel isolated from peer group, while in adult life they appear to be less successful in their jobs than normal-height persons. The remedy for those children is successfully attained in majority of cases by treatment with recombinant human growth hormone. The mentioned treatment is therefore applied in many countries and is planned to be introduced in our country in forthcoming years. Hence, in order to investigate the extent of short stature problem in IUGR and to identify the responsible factors, we have conducted the first survey in our country. The survey encompassed 414 preadolescent children (aged 6-9) out of 562 born with IUGR (< 10 centile) and 1000 randomly selected (500 girls and 500 boys) children out of 8108 individuals with body mass appropriate for gestational age ( 10 centile). The survey excluded children with other than IUGR causes of growth disorders. It was demonstrated that IUGR affects 6.6% of live birth children. Conclusions: 1. Around 9.5% chil ; dren born with IUGR exhibits short stature, i.e. below (-2) SDS and below average height of parents, during preadolescence age. This represents an almost three-fold increase in comparison to children with body mass appropriate for gestational age. 2. Over 90% of children born with IUGR reach correct stature during preadolescence time, consistent with their parental height that is not different from the stature of children with body mass appropriate for gestational age. 3. Factors that predispose to short stature during preadolescence among children born with IUGR are stimulants used by mothers during pregnancy, such as smoking tobacco and drinking alcohol, as well as increasing parity and residing in rural areas during pregnancy. Factors such as duration of pregnancy, maternal age and parental height were found to be not significant from the examined material.

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2 - studia doktoranckie

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Wydział Lekarski


Starzyk, Jerzy



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Praca doktorska

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