Title:

Procalcitonin as an early and uninvasion marker of pulmonary complications in patients with multiple trauma

Author:

Nazimek, Rafał

Subject:

procalcitonin ; ALI ; ARDS ; multiple trauma

Abstract:

Severe, multiple and multi-organ body contusion still constitute a major diagnostic and therapeutic problem, and mortality caused by it remains high, i.e. from 10 to 25%. When growing numbers of accident victims survive the period of medical transportation to a hospital, are helped out of traumatic shock and become effectively operated on, an increasing role is played by late complications occurring after a contusion. Those patients die during subsequent days and weeks because of the SIRS, including infective and pulmonary complications (ALI and ARDS). Therefore the awareness of occurrence of possible complication markers provides a chance for avoiding them. Parameter that could prove valuable prognostic factors is, among others, the behaviour of some cytokines and hormones, including procalcitonin (PCT). 40 in-patients were included to this study. 20 of them sustained severe, multiple contusions of average 12.70 ± 4.17 LSO point. The other 20 patients sustained light injuries of 2 LSO point severity (control group). Statistically significant difference was indicated between patients without complications and patients with ALI or ARDS, with simultaneous lack of statistically significant difference between patients with ALI and patients with ARDS in relation to severity of injuries and increase in value of the analysed parameters, including PCT. Procalcitonin is a highly promising early marker of pulmonary complications in patients with MOC. Increasing concentration of the compound was related to severity of contusion, and proved to be particularly distinct in case of contusion of head, chest, abdomen and spine.

Level of degree:

2 - studia doktoranckie

Degree discipline:

chirurgia

Degree grantor:

Wydział Lekarski

Promoter:

Leszek Brongel

Date:

2008

Date issued:

2008

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-109402

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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