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Title: Synthesis and pharmacological properties of novel derivatives of [gamma]-butyrolacotone and amides of [gamma]-hydroxybutyric acid

Author:

Więckowski, Krzysztof

Date:

2008

Type:

Praca doktorska

Abstract:

The aim of this study was rational design, synthesis and determination of physicochemical and pharmacological properties of series of new yhydroxybutyric acid (GHB) and y-butyrolactone (GBL) derivatives. The main part of the study was chemical synthesis of about hundred compounds utilizing different classical and modern methods, e.g. microwave-assisted organie synthesis (MAOS). For selected compounds various physicochemical descriptors were assigned with the use of computational and experimental methods as well. The pharmacological tests carried out as a part of the Anticonvulsant Screening Project (ASP, NIH, Rockville, USA) and in collaboration with Dept. of Pharmacodynamics of Jagiellonian University, revealed anticonvulsant and strong analgesic activity of some derivatives. Results of chemical and pharmacological investigations and SAR analysis led to select the most anticonvulsant and analgesic active compounds for further extending testing.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Malawska, Barbara

Date issued:

2008

Identifier:

oai:dl.cm-uj.krakow.pl:854

Call number:

ZB-109394

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

analgesic activity chemical synthesis [gamma]-methoxybutyramides anticonvulsant activity [gamma]-hydroxybutyramides

Object collections:

Last modified:

Feb 10, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

16

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/854

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Edition name Date
ZB-109394 Feb 10, 2023

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