This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: The analysis of effectiveness and costs of using low-molecular-weight heparins in comparison with oral anticoagulants for the treatment of venous thromboembolism


OBJECTIVE: The currently recommended standard treatment of venous thromboembolism (VTE) are oral anticoagulants (OA) in majority of patients and low-molecular-weight heparins (LMWH) in selected subpopulations. The titration of OA doses is difficult and often ineffective. The goal of this research was to compare LMWH and OA in VTE treatment, in terms of effectiveness, safety and cost-effectiveness. METHODS: The systematic review of scientific literature and the metaanalysis of reported treatment outcomes were performed. The cost analysis and the cost-effectiveness analysis were performed. The data on costs of treatment were collected through the retrospective review of patient records obtained from three hospitals and anticoagulation clinic, pharmaceutical reimbursement databases and public payer’s charge tariffs for medical services. The modeling (decision tree) was performed. RESULTS: The most important differences between LMWH and OA, in favor of LMWH, were related to better prevention of VTE incidence and better prevention of small bleedings. With respect to none of assessed outcomes OA were better than LMWH. Within a six month treatment period the ICER ratio of avoiding the complication incidents was 49.865 zlotys (12.242 EURO) from payer perspective and 3.609 zlotys (887 EUR) from patient perspective. CONCLUSION: LMWH offer better effectiveness and safety than OA but the t ; reatment is associated with considerably higher costs. Medical considerations support more general use of LMWH in VTE treatment but the economic constraints are essential barrier in dissemination of this method of treatment.

Place of publishing:


Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski


Niżankowski, Rafał

Date issued:




Call number:




Access rights:

tylko w bibliotece

Object collections:

Last modified:

Mar 13, 2023

In our library since:

Nov 21, 2012

Number of object content hits:


Number of object content views in PDF format


All available object's versions:


Show description in RDF format:


Show description in OAI-PMH format:


Edition name Date
ZB-113854 Mar 13, 2023


Citation style:

This page uses 'cookies'. More information