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Title: Prognostic value of circulating endothelial progenitor cells counts in stable angina patients undergoing elective percutaneous coronary intervention

Author:

Szastak, Grzegorz

Date:

2011

Type:

Praca doktorska

Abstract:

Our aim was: a/ To estimate the prognostic value of blood counts of endothelial progenitor cells (EPC) in a homogenous group of medically treated stable angina after a complex elective percutaneous coronary intervention; b/ To assess whether the hypothetical relationship between EPC and prognosis is independent of traditional and nontraditional risk factors. The results suggest that: a/ Circulating EPC deficiency and elevated asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) formation inhibitor, synergistically increase the coronary events risk in pharmacologically treated stable angina patients after elective coronary stenting. b/ The low EPC–high ADMA synergistic prognostic interaction is independent of the traditional and remaining estimated nontraditional risk factors, including other biochemical indices of endothelial dysfunction and parameters of inflammatory activation. c/ The low EPC–high ADMA synergistic prognostic interaction may result from the joint participation of EPC and NO in the maintenance of coronary endothelial integrity. d/ If confirmed by a larger study, the observed associations could be helpful in pre-procedural risk stratification and might possibly be even accentuated for EPC capturing stents coated with anti-CD34 antibodies.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Andrzej Surdacki

Date issued:

2010

Format:

application/msword

Identifier:

oai:dl.cm-uj.krakow.pl:836

Call number:

ZB-113853

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

endothelial progenitor cells prognosis stable angina percutaneous coronary intervention asymmetric dimethylarginine

Object collections:

Last modified:

Oct 15, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/836

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Edition name Date
ZB-113853 Oct 15, 2019

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