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Ta publikacja jest chroniona prawem autorskim. Dostęp do jej cyfrowej wersji jest możliwy z określonej puli adresów ip.

Tytuł: Design of new cholinesterases inhibitors by applying of molecular modeling techniques

Autor:

Bajda, Marek

Data:

2010

Typ:

Praca doktorska

Abstrakt:

Investigations within PhD thesis concerned design of new cholinesterases inhibitors as potential drugs in Alzheimer’s disease by applying of molecular modeling techniques. In the theoretical part the issues of Alzheimer’s disease were described. The special attention to cholinesterases as therapeutic targets was paid. Cholinesterases’ structure and inhibitors, used in the therapy of AD, were described. In the experimental part results of molecular modeling, joined with design of new cholinesterases inhibitors, were described. In the first step library of own compounds was prepared, basing on substances which were synthesized in the Department of Physicochemical Drug Analysis UJ and also planned for synthesis. A series of carbamates was obtained. Its activity was tested by Ellman’s method. Electrophoretically mediated microanalysis was evaluated as rapid method for determination of activity. Physicochemical and pharmacokinetic properties were predicted and structure - activity relationships were found. Interactions between compounds and AChE or BuChE were described. New cholinesterases inhibitors were designed. Compounds from ZINC database were under virtual screening with pharmacophores and docking procedure.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

farmacja ; biochemia

Instytucja nadająca tytuł:

Wydział Farmaceutyczny

Promotor:

Malawska, Barbara

Data wydania:

2010

Identyfikator:

oai:dl.cm-uj.krakow.pl:816

Sygnatura:

ZB-113593

Język:

pol; eng

Prawa dostępu:

tylko w bibliotece

Temat i słowa kluczowe:

cholinesterases inhibitors Ellman’s method chemical synthesis molecular modeling electrophoretically mediated microanalysis

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

10 mar 2023

Data dodania obiektu:

21 lis 2012

Liczba wyświetleń treści obiektu:

29

Liczba wyświetleń treści obiektu w formacie PDF

0

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/816

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-113593 10 mar 2023

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