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Title: Autonomic system in patients with constipation predominant irritable bowel syndrome


The main mechanism underlying the irritable bowel syndrome (IBS) is currently believed to be dysfunction of the brain-gut axis. Autonomic nervous system (ANS) dysfunction can contribute to IBS symptoms development by disturbing visceral sensation. 30 patients with a diagnosis of constipation predominant IBS and 30 healthy volunteers were included in the study. Resting and functional ANS tests and percutaneous electrogastrography (EGG) were performed. Serum adrenalin, noradrenalin, insulin, ghrelin and cholecystokinin activity was analyzed. Increased sympathetic activation with disturbed parasympathetic function in was demonstrated. Patients had substantially higher serum catecholamines concentrations, which confirms sympathetic overbalance. Hyperinsulinaemia may explain sympathetic predominance followed by gastric and intestinal motility deceleration. Abnormal, reduced ghrelin and cholecystokinin titre may disturb brain-gut axis functioning and may be responsible for gastric motility deceleration. In EGG distinctly lower values of fasting normogastria percentage and dominant power (DP) were observed. Patients had substantively lower slow wave coupling (SWC) percentage both in fasting and postprandial period, which negatively correlated with serum catecholamines level. Gastric myoelectrical activity disturbances may result from lack of sympatho-parasympathetic equilibrium. Within the brain-gut axis it is most probably central sympathetic influence that is responsible for myoelectrical activity disturbances in IBS patients.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego ; patofizjologia

Degree grantor:

Wydział Lekarski


Piotr J. Thor

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Oct 8, 2019

In our library since:

Nov 21, 2012

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Edition name Date
ZB-112129 Oct 8, 2019


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