Advanced search ?

Object

Access Limited

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Correlation between polimorfizm of GTP cyclohydrolase 1 and endothelial dysfunction in patients with type 2 diabetes

Author:

Kosiniak-Kamysz, Władysław

Date:

2010

Type:

Praca doktorska

Abstract:

The bioavailability of tetrahydrobiopterin (BH4) is critical in the regulation of vascular function, as it controls the balance between the production of nitric oxide and superoxide by the endothelial nitric oxide synthase. Recent evidence suggests that genetic variation of GTP cyclohydrolase I, a rate limiting enzyme in BH4 production may be important in regulating vascular function. While some papers point to a “pain protective haplotype“ (rs10483639, rs3783641, rs8007267) as critical for vascular function, others indicate the rs841 3’UTR polymorphism is important. . Polymorphisms created two haplotype blocks in polish diabetics population: rs10483639, rs841, rs3783641, and second rs10137071 rs8007267. Haplotype block 1 was associated with plasma markers of oxidative stress and endothelial integrity, with the strongest association for rs841, although all studied SNPs showed statistically significant relationships. Interestingly, flow mediated dilatation, a marker of endothelial function, was only associated with the rs841 polymorphism and not with the remainder of the haplotype block. Interestingly, in this diabetic cohort, none of the GTP-CH1 polymorphisms were associated with carotid atherosclerosis as measured by intima-media thickness. These studies identify the rs841 polymorphism of the GTP cyclohydrolase I gene as a critical determinant of both vascular function and oxidative stress while the “pain protective haplotype” is most likely a marker of this association. Studies of how the rs841 polymorphism affects GTP-CH1 mRNA and protein levels are needed to define its role in vascular disease.

Level of degree:

2 - studia doktoranckie

Degree discipline:

genetyka ; patofizjologia ; biochemia

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Guzik

Date issued:

2010

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:800

Call number:

ZB-112127

ControlNumberVIRTUA:

click here to follow the link

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

GTP cyclohydrolase 1 tetrahydrobiopterin nitric oxide endothelium diabetes type 2

Object collections:

Last modified:

Oct 8, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

3

Number of object content views in PDF format

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/800

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-112127 Oct 8, 2019

Objects

Similar

Correlation between polimorfizm of GTP cyclohydrolase 1 and endothelial dysfunction in patients with type 2 diabetes

Kosiniak-Kamysz, Władysław

2010
Praca doktorska

The role of endothelium and disturbances of blood flowautoregulationin the pathogenesis of reflex syncope

Wnuk, Mateusz

2012
Praca doktorska

Role of vascular endothelial adaptation in regulation of exercise capacity, platelet activation and post-exercise endothelial function in mice

Przyborowski, Kamil

2019
Praca doktorska

Coronary endothelial dysfunction in heart failure in Tgαq*44 mice

Drelicharz, Łukasz

2006
Praca doktorska

Carotid atherosclerosis versus plasma levels of an endogenous nitric oxide synthesis inhibitor in rheumatoid arthritis

Włoch, Alicja

2007
Praca doktorska

The role of clinical and genetical risk factors in pathogenesis of diabetic retinopathy in patients with type 2 diabetes

Cyganek, Katarzyna

2007
Praca doktorska

Nitric oxide and the activity of NADPH oxidase in rat granulocytes after stimulation with lipopolysaccharide in vitro

Salwińska, Magdalena

2011
Praca doktorska

The investigation of mechanism 1-methylnicotinamide (MNA+) in animal models of endothelial dysfunction

Bartuś, Magdalena

2007
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information