Alterations of endothelial excretory function in the coronary circulation during development of atherosclerosis in apoE/LDLR-/- mice - Digital Medical Library

Skip to main menu
Skip to search engine
Skip to content
Skip to footer

Download

Description
Information

Title: Alterations of endothelial excretory function in the coronary circulation during development of atherosclerosis in apoE/LDLR-/- mice

Author:

Gwóźdź, Paweł

Date:

Type:

Praca doktorska

Abstract:

Activation of circulating platelets accompanies hipercholesterolemia and atherosclerosis and may be caused by impairment of endothelial antiplatelet activity. The aim of this work was to characterise the activity of the main endothelial antiplatelet and antiinflammatory mechanisms (NO, PGI2 and adenosine) in the coronary circulation in hypercholesterolemic mice along the development of atherosclerosis. NO-dependent, PGI2-dependent and adenosine-dependent vasodilations were investigated in the isolated hearts of apoE/LDLR-/- mice before atherosclerosis development and in the presence of atherosclerotic lesions. Levels of metabolites of PGI2 and adenosine in the coronary effluent and the concentration of sCD40L and SAA in plasma were determined. HbNO level in erythrocytes, circulating platelet membrane expression of P-selectin, CD40L and aGPIIb-IIIa and mice exercise capacity were also determined. In apoE/LDLR-/- mice, before development of atherosclerosis, systemic bioavaibility of NO is impaired and circulating platelet CD40L-dependent activity is increased. In the coronary circulation, NO-dependent endothelial function is not impaired and sensitivity to NO and PGI2 production is augmented. In young apoE/LDLR-/- mice, intracoronary adenosine production is impaired and the sensitivity of coronary arteries to adenosine is increased; these phenomena disappear with age. Exercise capacity is preserved, and systemic PGI2 production is increased during exercise. These results suggest that in ApoE/LDL-/- mice adaptive alterations of endothelial NO-, PGI2- and adenosine-dependent function are present and may provide the explanation for the preservation of exercise capacity.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Stefan Chłopicki

Date issued:

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:788

Call number:

ControlNumberVIRTUA:

click here to follow the link

Access rights:

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

hypercholesterolemia atherosclerosis endothelium platelets coronary circulation

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Oct 7, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

791

Number of object content views in PDF format

787

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/788

Show description in RDF format:

Show description in OAI-PMH format:

Edition name	Date
ZB-111800	Oct 7, 2019

Objects

Similar

Alterations of endothelial excretory function in the coronary circulation during development of atherosclerosis in apoE/LDLR-/- mice

Gwóźdź, Paweł

2010

Praca doktorska

Role of vascular endothelial adaptation in regulation of exercise capacity, platelet activation and post-exercise endothelial function in mice

Przyborowski, Kamil

2019

Praca doktorska

Assessment of the relationship between endothelial function, aortic stiffness and the extent of atherosclerosis

Kopeć, Grzegorz

2007

Praca doktorska

The influence of platelet glycoprotein IIIa polymorphism on antithrombotic effects of aspirin and clopidogrel in patients with atherosclerosis

Dyszkiewicz-Korpanty, Anna

2005

Praca doktorska

The influence of lipoxin A4 on human platelet function in dynamic in vitro tests

Węgrzyn, Wojciech

2014

Praca doktorska

Influence of autoimmunity on endothelial dysfunction and atherosclerosis development in young patients with coronary artery disease and in systemic lupus erythematosus patients

Mazurek, Adam

2020

Praca doktorska

Selected aspects of endothelial dysfunction in patients with type 2 diabetes

Waluś-Miarka, Małgorzata

2008

Praca doktorska

Coronary flow reserve alterations related to clinical,echocardiographic and biochemical parameters after aortic valvereplacement due to severe stenosis

Nosal, Marcin

2016

Praca doktorska

More

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

https://bm.cm.uj.edu.pl/en/main-page/

This page uses 'cookies'. More information