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Title: The influence of phytoestrogens on the reproductive system in male mice


Phytoestrogens are the group of substances which naturally can be found in many plants. The richest sources of phytoestrogens in human’s diet are soy and soy products. Phytoestrogens have similar structure to main female sex hormone 17β estradiol, therefore displaying mimic effects of this hormone in organism. The aim of the dissertation was to investigate if phytoestrogens are able to influence on the functions of male reproductive system. Male Balb/c mice were fed three kinds of special prepared animal chows that differed in content of soy, and in this way in content of phytoestrogens. The experiments comprised prenatal and prepubertal stages as well as mice adulthood. The histological changes in testes of animals fed the chow with soy showed: disturbance of spermatogenesis, delay of germinal cell divisions, degeneration of seminal tubule epithelium, decrease in number of mature sperm cells and their lower viability. Moreover, phytoestrogens displayed effects on height of epithelial cells in caput, corpus and cauda of the epididymis. Phytoestrogens can disturb hormonal balance of male mice. The experiments revealed the increase of estradiol level in blood serum and decrease the number of estrogen receptors type β in epithelial cells of the epididymis of adult males, which were fed chow containing phytoestrogens. In addition, daidzein, one of phytoestrogens, injected intraperitoneally in chemical pure form, caused more marked histological changes in testes of adult mice that phytoestrogens served in chow. The results of experiments show that phytoestrogens can disturb not only maturation of reproductive system in male mice, but also his functions and, in this way the fertility in adulthood. However, the direct mechanisms influencing of these substances on the organism are still unclear. Therefore, the further research is required to elucidate the molecular actions of phytoestrogens on cells.

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; fizjologia

Degree grantor:

Wydział Lekarski


Leopold Śliwa

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Oct 2, 2019

In our library since:

Nov 21, 2012

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Edition name Date
ZB-111538 Oct 2, 2019


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