Obiekt

Tytuł: Persistent infection with human rhinovirus of lower airways and clinical state of asthmatic patients

Abstrakt:

Human rhinovirus (HRV), the common cold virus is the most frequent cause of asthma exacerbations in adults. Our objectives were to determine if stable asthmatic patients, who are free of clinical symptoms of a respiratory infection, can harbor HRV in their bronchi, and to compare the frequency of HRV detection between asthmatic and nonasthmatic subjects. We also were concerned whether clinical features of asthma are associated with the presence of HRV. Two methods of HRV detection in bronchial mucosa were used: indirect RTPCR in situ method and indirect immunohistochemistry (IHC). HRV was found by IHC in 64% asthmatic subjects and 33% non-asthmatic controls. Indirect RT-PCR in situ method detected HRV in 73% of asthmatic patients and 22% non-asthmatic controls (p<0,001). Subjects positive for HRV had lower pulmonary function tests, higher numbers of blood eosinophils, leukocytes, granulocytes, and eosinophilic infiltration in bronchial mucosa Asthmatic patients, who are free of clinical symptoms can harbor HRV in the lower airways. The presence of HRV in bronchial tissue is significantly more common in asthmatic than in non-asthmatic subjects. Presence of HRV was associated with clinical features of more severe disease.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

pulmonologia ; mikrobiologia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Sanak, Marek

Data wydania:

2009

Identyfikator:

oai:dl.cm-uj.krakow.pl:754

Sygnatura:

ZB-111533

Język:

pol

Prawa dostępu:

nieograniczony

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

21 lis 2012

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1 037

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121

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/754

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Nazwa wydania Data
ZB-111533 26 cze 2023
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