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Title: Glutathione deficiency and alterations in the sulfur amino acid homeostasis during early postnatal development as potential triggering factors for schizophrenia-like behavior in adult rats
Abstract:
Schizophrenia is a mental illness that includes positive and negative symptoms and cognitive deficits. The etiology of this disease is associated with the interaction of genetic and environmental factors, especially during early brain development. Glutathione (GSH) deficiency and redox homeostasis disorders play an important role in the pathophysiology of schizophrenia, leading to oxidative stress and neuronal damage. The aim of the doctoral thesis was to develop an animal, neurodevelopmental model of schizophrenia based on GSH deficiency and sulfur amino acid homeostasis disorders, characterize this model biochemically and behaviorally, and evaluate its usefulness using selected drugs. Schizophrenic-type changes were induced by postnatal administration of buthioninesulfoximine (GSH synthesis inhibitor) and GBR 12909 (dopamine reuptake inhibitor) to animals. Biochemical analyses revealed significant changes in the concentrations of sulfur amino acids and in the activities of antioxidant enzymes in the prefrontal cortex and hippocampus, which disturbed the redox balance. Social and cognitive deficits and increased mobility were observed in adult rats. N-acetylcysteine and aripiprazole effectively reversed the disorders corresponding to the symptoms of schizophrenia and had significant effects on the anaerobic cysteine metabolism in the hippocampus, which suggests that modeling t ; he cysteine transformations in the brain may be a new therapeutic target in the treatment of schizophrenia. The developed model may be useful in the study of schizophrenia and the search for new therapeutic strategies.
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Rada Dyscypliny Nauki medyczne
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Lorenc-Koci, Elżbieta ; Iciek, Małgorzata
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Last modified:
Mar 27, 2025
In our library since:
Mar 27, 2025
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http://dl.cm-uj.krakow.pl:8080/publication/5247
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| Edition name | Date |
|---|---|
| ZB-142296 | Mar 27, 2025 |
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