Comparison of fractional flow reserve with resting non-hyperemic indices in patients with coronary artery disease - Digital Medical Library

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Title: Comparison of fractional flow reserve with resting non-hyperemic indices in patients with coronary artery disease

Author:

Zdzierak, Barbara

Date:

Type:

Praca doktorska

Abstract:

Currently, fractional flow reserve (FFR) and invasive methods that do not reqmre hyperemia (iwFR) are recommended for assessing the functional significance oj coronary artery lesions. Methods that do not require hyperemia include instantaneous wave-free ratio (iFR) and resting full-cycle ratio (RFR). There is ample evidence of the good correlation between hyperemic and non-hyperemic methods of evaluating the significance of coronary artery stenoses. However, m approximately 20% of cases, discordance between FFR and iwFR results is observed. This dissertation 1s identifying factors influencing the discrepancies between FFR and iwFR. Age emerged as a predictor of discordance between positive FFR and negative iFR/RFR results. Atrial fibrillation was identified as an independent predictor of overall discrepancies between FFR and iwFR in multivariate analysis. Insulin-treated diabetes was associated with an increased risk of negative FFR and positive iwFR results. Sex was not associated with an increased risk of discrepancy between FFR and iw FR results. In conclusion, when interpreting "gray-zone" FFR values, it is essential to exercise caution and consider the use of nonhyperemic methods (iFR/RFR). This may be critical m patients with multiple factors that may contribute to discrepancies between FFR and iFR/RFR results, including age, diabetes mellitus, or atrial fibrillation.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Dziewierz, Artur

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:5184

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Language:

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tylko w bibliotece

Subject and keywords:

FFR iwFR iFR RFR

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jan 16, 2025

In our library since:

Jan 16, 2025

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http://dl.cm-uj.krakow.pl:8080/publication/5185

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Edition name	Date
ZB-141642	Jan 16, 2025

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Comparison of fractional flow reserve with resting non-hyperemic indices in patients with coronary artery disease

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2024

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