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Krawczyk, Agnieszka
2024
Praca doktorska
Crohn's disease (CD) is a chronic, inflammatory disease of the gastrointestinal tract, classified as inflammatory bowel disease. The pathogenesis of this disease is stili unknown, making effective treatment and prevention impossible.Due to the fact that both fungi and archaea are an important component of the commensal microbiome, it is possible that a change in their number or composition may affect the occurrence of same diseases, including CD, which was the research hypothesis of this do,ctoral dissertation. The conducted research showed numerous changes in the composition of intestinal fungi and archaea among patients with CD. lmportantly, the optimization of sequencing for archaeome analysis contribute to comprehensive assessment of the composition of these microorganisms, which enabled the observation of novel, interesting relationships occurring in the archaeal population during the course of the CD. The conducted analyses made it possible to determine microorganisms characteristic of a given study group. lt seems that same microorganisms may constitute a specific non-invasive biomarker of the activity of Crohn's disease, which may be helpful in predicting the exacerbation or assessing the chronicity of this disease.
Kraków
2 - studia doktoranckie
mikrobiologia
Rada Dyscypliny Nauki medyczne
Gosiewski, Tomasz ; Salamon, Dominika
2023
oai:dl.cm-uj.krakow.pl:5170
ZB-141569
pol; eng
tylko w bibliotece
7 mar 2025
26 lis 2024
6
0
http://dl.cm-uj.krakow.pl:8080/publication/5171
RDF
OAI-PMH
Szczeklik, Katarzyna
Herman, Roma
Brzozowski, Bartosz
Rozpondek, Piotr
Holko, Przemysław
Wasilewska, Agata
Kaczmarczyk, Olga
Styl cytowania: chicago-author-date iso690-author-date chicago-author-date
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