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Title: Metagenomic analysis of intestinal archaeome and mycobiome in pediatric patients with Crohn's disease compared to healthy children

Author:

Krawczyk, Agnieszka

Date:

2024

Type:

Praca doktorska

Abstract:

Crohn's disease (CD) is a chronic, inflammatory disease of the gastrointestinal tract, classified as inflammatory bowel disease. The pathogenesis of this disease is stili unknown, making effective treatment and prevention impossible.Due to the fact that both fungi and archaea are an important component of the commensal microbiome, it is possible that a change in their number or composition may affect the occurrence of same diseases, including CD, which was the research hypothesis of this do,ctoral dissertation. The conducted research showed numerous changes in the composition of intestinal fungi and archaea among patients with CD. lmportantly, the optimization of sequencing for archaeome analysis contribute to comprehensive assessment of the composition of these microorganisms, which enabled the observation of novel, interesting relationships occurring in the archaeal population during the course of the CD. The conducted analyses made it possible to determine microorganisms characteristic of a given study group. lt seems that same microorganisms may constitute a specific non-invasive biomarker of the activity of Crohn's disease, which may be helpful in predicting the exacerbation or assessing the chronicity of this disease.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Gosiewski, Tomasz ; Salamon, Dominika

Date issued:

2023

Identifier:

oai:dl.cm-uj.krakow.pl:5170

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

Crohn's disease NGS archaeome mycobiome gut micro biota molecular microbiology

Object collections:

Last modified:

Nov 26, 2024

In our library since:

Nov 26, 2024

Number of object content hits:

0

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5171

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Edition name Date
UJCMb00ea5ccdd7f4e40b28354acfc425ac3 Nov 26, 2024

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