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Title: Assessment of oxidative stress markers in patients with a diagnosis of idiopathic infertility
Abstract:
Background Infertility is currently defined by the World Health Organization (WHO) as the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse (3-4 times a week). The problem currently affects 10-15% of the world's population and in Poland 0.7-1.0 million couples require diagnosis and treatment. Infertility is caused by both female and male factors, and in many cases both coexist. The probability of spontaneous conception decreases with the duration of Infertility. The decline in fertility in women starts as early as around 25-30 years of age, due to the rapidly decreasing number of primary follicles in the ovary. 85% of the causes of difficulties achieving pregnancy are identifiable, with the remaining 15% described as idiopathic infertility. Oxidative stress plays an important role in critical biological processes in human reproduction but as we age, reproductive cells are particularly sensitive to oxidative stress. An imbalance between ROS and protective antioxidants can cause both difficulties in achieving and maintaining a pregnancy. Infertility is one of the most stressful health conditions among partners and also a significantly life-changing condition that can lead to significant psychological trauma. In addition, infertility affects not only the individual affected, but also the general demographics and ; well-being of society as a whole. Aim The aim of this study is to investigate the differences between the levels of selected oxidative stress markers (MDA, SOD, AGEs, GPx) in a population of women with idiopathic infertility compared to women with naturally conceived offspring and to prove the relationship between oxidative stress and infertility. In the next step, the relationship between oxidative stress markers and the AMH levels and BMI of the patients is investigated. Finally, the study assesses the dietary habits and the presence of antioxidants in the diet of female patients and their association with the diagnosis of infertility. Material and methods The study material consisted of a group of 41 women diagnosed with primary or secondary infertility, and a control group of 40 patients with naturally conceived offspring. Patients were recruited from among women hospitalised in the Department of Gynaecological Endocrinology and Gynaecology for hormonal diagnosis and who were under consultation within the Comprehensive Procreative Health Programme. The study design received a positive opinion from the Jagiellonian University Bioethics Committee No. 1072.6120.9.2020 of 23 rd January 2020. Venous blood was collected for the identification of the level of oxidative stress markers. AMH results were obtained as part of the determinations performed at the Procr ; eation Outpatient Clinic. Patients’ weight and height were measured to obtain BMI. Additionally, patients independently completed the QEB Questionnaire for the Study of Eating Behaviour and Opinions on Food and Nutrition. Summary of findings The study confirms that high antioxidant status of the body adversely affects reproductive capacity in a group of women with idiopathic infertility. Oxidative stress markers cannot serve as a predictive indicator of ovarian reserve expressed as AMH in women with idiopathic infertility. Levels of obesity and being overweight do not correlate with oxidative stress levels. A dietary model similar to the Mediterranean diet should be recommended to patients trying for pregnancy.
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Rada Dyscypliny Nauki medyczne
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Last modified:
Oct 9, 2024
In our library since:
Oct 9, 2024
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10
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1
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http://dl.cm-uj.krakow.pl:8080/publication/5166
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| Edition name | Date |
|---|---|
| ZB-140537 | Oct 9, 2024 |
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