Advanced search ?

Object

Download

Title: Molecular epidemiology of clinical strains Klebsiella pneumoniae, population clonal structure, virulence and antibiotic resistance

Author:

Ochońska, Dorota

Date:

2024

Type:

Praca doktorska

Abstract:

Klebsiella pneumoniae is one of the most common agents of nosocomial infections with a severe course and high mortality rate, especially in intensive care patients. This bacterium is characterized by high adaptability, resistance to numerous antibiotics, the presence of numerous virulence factors and the ability to form biofilms on the surfaces of various biomaterials. The aim of the study was to perform a detailed characterization of clinical strains of K. pneumoniae isolated from patients hospitalized in three specialist hospitals in Poland. The laboratory tests carried out included species identification, determination of drug resistance profiles along with resistance phenotypes, detection of resistance genes, genotyping and detection of genes encoding selected virulence factors. In the created collection of 172 clinical strains of K. pneumoniae, 82.6% of isolates producing ESβL β-lactamases and 8.7% of carbapenem-resistant isolates producing KPC, VIM-1, OXA-48 carbapenemases were identified. Among the resistance genes, blaSHV was dominant, detected in 82.4% of isolates, while among virulence genes, the most common was the entB gene (91.4%). In the course of molecular typing, a hyperepidemic ST147 clone of international distribution was identified in the studied population of enterobacteria.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Brzychczy-Włoch, Monika

Date issued:

2023

Identifier:

oai:dl.cm-uj.krakow.pl:5136

Call number:

ZB-139915

Language:

pol; eng

Access rights:

nieograniczony

Subject and keywords:

antibiotic resistance Klebsiella pneumoniae hospital molecular epidemiology virulence

Object collections:

Last modified:

Jun 18, 2024

In our library since:

Jun 18, 2024

Number of object content hits:

6

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5137

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-139915 Jun 18, 2024

Objects

Similar

Molecular epidemiology of clinical strains Klebsiella pneumoniae, population clonal structure, virulence and antibiotic resistance

Ochońska, Dorota

2024
Praca doktorska

Application of molecular methods to the diagnosis of invasive fungal infections and clinico-epidemiological analysis of fungal infections in hospitalized patients

Małek, Marianna

2016
Praca doktorska

Restructuring of hospitals as a tool of the healthcare reform

Karkowski, Tomasz

2007
Praca doktorska

Virulence factors of selected Gram-positive cocci causing invasive infections, especially in peri-labor women and newborns with low birth weight

Golińska, Edyta

2021
Praca doktorska

Studies on molecular epidemiology of infections caused by antimicrobial resistant Enterobacteriaceae among very-low birth weight infants

Pobiega, Monika

2015
Praca doktorska

MED-INFO

e-czasopismo

Postępy Mikrobiologii

e-czasopismo

Koło Mikrobiologii Farmaceutycznej - Zakład Mikrobiologii Farmaceutycznej Uniwersytetu Jagiellońskiego Collegium Medicum

serwis informacyjny
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information