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Ochońska, Dorota
2024
Praca doktorska
Klebsiella pneumoniae is one of the most common agents of nosocomial infections with a severe course and high mortality rate, especially in intensive care patients. This bacterium is characterized by high adaptability, resistance to numerous antibiotics, the presence of numerous virulence factors and the ability to form biofilms on the surfaces of various biomaterials. The aim of the study was to perform a detailed characterization of clinical strains of K. pneumoniae isolated from patients hospitalized in three specialist hospitals in Poland. The laboratory tests carried out included species identification, determination of drug resistance profiles along with resistance phenotypes, detection of resistance genes, genotyping and detection of genes encoding selected virulence factors. In the created collection of 172 clinical strains of K. pneumoniae, 82.6% of isolates producing ESβL β-lactamases and 8.7% of carbapenem-resistant isolates producing KPC, VIM-1, OXA-48 carbapenemases were identified. Among the resistance genes, blaSHV was dominant, detected in 82.4% of isolates, while among virulence genes, the most common was the entB gene (91.4%). In the course of molecular typing, a hyperepidemic ST147 clone of international distribution was identified in the studied population of enterobacteria.
Kraków
2 - studia doktoranckie
mikrobiologia
Rada Dyscypliny Nauki medyczne
Brzychczy-Włoch, Monika
2023
oai:dl.cm-uj.krakow.pl:5136
ZB-139915
pol; eng
nieograniczony
Jul 17, 2024
Jun 18, 2024
23
16
http://dl.cm-uj.krakow.pl:8080/publication/5137
RDF
OAI-PMH
Małek, Marianna
Karkowski, Tomasz
Golińska, Edyta
Pobiega, Monika
Citation style: chicago-author-date iso690-author-date
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