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Title: Basophil activation test (BAT) in qualification for specific immunotherapy (VIT) in Hymenoptera venom allergy


According to European data, up to 95% of the population is stung by a wasp, bee or hornet at least once in their live. In most cases, the consequence is a local reaction, while up to 7.5% of those who are stung, experience systemic reaction. The only causal treatment may then be highly effective venom-specific immunotherapy -VIT. In addition to the clinical eligibility criteria for VIT, it is necessary to confirm the IgE-dependent mechanism of the post-sting reaction. This is achieved by skin testing with an insect venom solution and/or marking in the serum of venom-specific IgE. When the results of these tests are negative, inconsistent, or if double sensitization is suspected, the basophil activation test (BAT) may be useful. The aim of the study was to assess the usefulness of BAT in qualifying for VIT. In the group of patients who met the clinical criterion of qualification for VIT, routine diagnostic tests and BAT with wasp and bee venom solutions were carried out in order to verify the immunological criterion. In addition, using a visual analogue scale, the level of anxiety of the next sting was assessed. High sensitivity and high positive predictive value (PPV) of BAT were confirmed. The subjects were characterized by a high level of anxiety of the next sting. BAT turned out to be useful in the qualification for VIT of patients whose routine tests were negative and en ; abled the selection of venom for VIT in patients with suspected double allergy. A positive BAT result allowed to meet the immunological criterion of qualification for VIT and additionally 13 patients of the study group (16.5%) could take the only causal treatment.

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2 - studia doktoranckie

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Rada Dyscypliny Nauki medyczne


Czarnobilska, Maria

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tylko w bibliotece

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Jun 6, 2024

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Jun 6, 2024

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ZB-140021 Jun 6, 2024


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