Effect of carbonyl reductase 1 on the resistance of cancer cells to anthracvclines - Digital Medical Library

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Title: Effect of carbonyl reductase 1 on the resistance of cancer cells to anthracvclines

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Date:

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Praca doktorska

Abstract:

Anthracyclines are a group of oncological drugs commonly used in a therapy, and their wide spectrum of activity and high efficiency make them constituents of many chemotherapy regimens. Unfortunately, the activity of anthracyclines is often reduced due to the resistance of cancer cells, which limits the effectiveness and therapeutic potentia! of these drugs. Over the years, many mechanisms of drug resistance of can cer cells have been discovered. In the case of anthracyclines, a special role in resistance is attributed to transmembrane transporters, mainly from the ABC family, especially ABCBl, which, through the active efflux of drugs across the cell membrane, reduce intracellular concentrations of the drug, reducing their cytotoxic and cytostatic activity. In recent years, there has been increasing concern about the role of drug-metabolizing enzymes in the course of resistance. In the case of anthracyclines, these are cytosolic enzymes from the group of short-chain dehydrogenases/reductases - carbonyl reductases and aldo-keto reductases. These enzymes catalyse the reduction reaction of the carbonvl group of the side chain

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne

Promoter:

Pękala, Elżbieta ; Koczurkiewicz-Adamczyk, Paulina

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:5118

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tylko w bibliotece

Subject and keywords:

anthracyclines biotransformation cancer cell resistance carbonvl reductase 1 ABCBl transporter

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

May 23, 2024

In our library since:

May 23, 2024

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http://dl.cm-uj.krakow.pl:8080/publication/5119

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Edition name	Date
ZB-140036	May 23, 2024

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