Advanced search ?

Object

Access Limited

This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Evaluation of anti-inflammatory activity of zinc derivatives of xanthonyloxyalkanoic acids

Author:

Lipkowska, Anna

Date:

2023

Type:

Praca doktorska

Abstract:

Zinc is a bioelement that has anti-inflammatory and antioxidant properties and 1s gastroprotective. Both natura! xanthone derivatives and their synthetic analogs have anti-inflammatory properties. This study aimed to evaluate the anti-inflammatory activity of zinc derivatives of xantonylooxyalkanoic acid. The effect of the tested compolmds on the inhibition of edema and nociceptive reaction in animals was evaluated. In .addition, the effect of the tested compounds on antioxidant activity, the level of proteins, and proinflammatory genes in cell models were determined. In an experiment conducted on rats, the antiinflammatory activity of the tested compounds was demonstrated. At the same time, gastrotoxicity has not been demonstrated, unlike the widely used NSAIDs. The study of analgesic activity in the formalin model did not confirm the anti-inflammatory activity of zinc derivatives. Experiments conducted on cell lines confirmed the anti-inflammatory activity of the tested compounds. In addition, the results clearly indicate the high antioxidant potentia! of zmc derivatives of xantony looxyalkanoic acid. A wide range of research conducted to find new antiinflammatory drugs that do not cause side eff ects suggests that zinc derivatives of xantonylooxyalkanoic acids should be the subject of further pharmacological research.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne

Promoter:

Librowski, Tadeusz

Date issued:

2023

Identifier:

oai:dl.cm-uj.krakow.pl:5102

Call number:

ZB-139417

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

xanthone derivatives zmc anti-inflammatory activity

Object collections:

Last modified:

Apr 29, 2024

In our library since:

Apr 29, 2024

Number of object content hits:

0

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5103

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-139417 Apr 29, 2024

Objects

Similar

Evaluation of anti-inflammatory activity of zinc derivatives of xanthonyloxyalkanoic acids

Lipkowska, Anna

2023
Praca doktorska

Influence of zinc ions on the activity of non-steroidal anti-inflammatory drugs (NSAIDs)

Jarosz, Magdalena

2017
Praca doktorska

Evaluation of anti-inflammatory activity of extracts fromselected species of edible mushrooms and their biomass usingmolecular biology techniques

Grzywacz-Kisielewska, Agata

2017
Praca doktorska

Antiarrhythmic and hypotensive properties of new xanthone derivatives with adrenolytic activity

Rapacz, Anna

2012
Praca doktorska

Synthesis of novel amide and hydrazide purine-2,6-dione and benzimidazole derivatives as TRPA1 channel antagonists with potential analgesic and anti-inflammatory activity

Ślusarczyk, Marietta Teresa

2022
Praca doktorska

Phytochemical analysis and biological activity ofcanadian fleabane (Erigeron canadensis L.Cronq) herb extracts

Ellnain, Marek

2013
Praca doktorska

Comparison of biological properties of taurine haloamines as potential agents in the treatment of inflammatory and infectious diseases

Walczewska, Maria

2017
Praca doktorska

Evaluation of anti-inflammatory effects of zinc oxide nanoparticles in vivo and in vitro models

Olbert, Magdalena

2019
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information