This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Evaluation of anti-inflammatory activity of zinc derivatives of xanthonyloxyalkanoic acids


Zinc is a bioelement that has anti-inflammatory and antioxidant properties and 1s gastroprotective. Both natura! xanthone derivatives and their synthetic analogs have anti-inflammatory properties. This study aimed to evaluate the anti-inflammatory activity of zinc derivatives of xantonylooxyalkanoic acid. The effect of the tested compolmds on the inhibition of edema and nociceptive reaction in animals was evaluated. In .addition, the effect of the tested compounds on antioxidant activity, the level of proteins, and proinflammatory genes in cell models were determined. In an experiment conducted on rats, the antiinflammatory activity of the tested compounds was demonstrated. At the same time, gastrotoxicity has not been demonstrated, unlike the widely used NSAIDs. The study of analgesic activity in the formalin model did not confirm the anti-inflammatory activity of zinc derivatives. Experiments conducted on cell lines confirmed the anti-inflammatory activity of the tested compounds. In addition, the results clearly indicate the high antioxidant potentia! of zmc derivatives of xantony looxyalkanoic acid. A wide range of research conducted to find new antiinflammatory drugs that do not cause side eff ects suggests that zinc derivatives of xantonylooxyalkanoic acids should be the subject of further pharmacological research.

Place of publishing:


Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne


Librowski, Tadeusz

Date issued:




Call number:




Access rights:

tylko w bibliotece

Object collections:

Last modified:

Apr 29, 2024

In our library since:

Apr 29, 2024

Number of object content hits:


Number of object content views in PDF format


All available object's versions:


Show description in RDF format:


Show description in OAI-PMH format:


Edition name Date
ZB-139417 Apr 29, 2024


Citation style:

This page uses 'cookies'. More information