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Title: Morphological features of the left atrial appendage in light of its prothrombogenic and proarrhythmogenic properties


The left atrial appendage is a structure that is being given significantly more physiological and clinical importance. Due to the discovery of its further pathophysiological features and the dynamic development of the appendage mechanical closure and electrical isolation techniques, the knowledge about its structure is gaining more and more importance. Detailed knowledge of the morphological properties of the left atrial appendage and their role in the pathogenesis of ischemic stroke may facilitate clinical decision-making, as well as improve planning and conducting procedures within the left atrial appendage. The aim of this dissertation thesis was: 1) to simplify the classification of the left atrial appendage to make it more clinically useful; 2) to examine detailed anatomy of the left atrium appendage; 3) to deliver morphometric analysis of the left atrial appendage orifice, with particular emphasis on the structure of the left atrium wall in the vicinity of the appendage orifice; 4) to investigate the morphometric differences between the left atrial appendages of patients with atrial fibrillation compared to the appendages of patients with sinus rhythm. W total of 200 hearts collected during autopsies were assessed macroscopically. Additionally, 101 3D reconstructions obtained from cardiac computed tomography with contrast enhancement were assessed (group of ; patients with and without atrial fibrillation). Current work presents a simplified, three-point classification of the left atrium appendage shape. The usefulness of the new classification was verified by reassessing reconstructions of cardiac computed tomography scans. The study also provided comprehensive, multidimensional data on the morphometry of the left atrial appendage and its orifice. Significant differences in the morphology of left atrial appendages were also demonstrated between groups with different rhythm status, and a reduced appendage ejection fraction was observed in patients with atrial fibrillation compared to patients without arrhythmia.

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Level of degree:

2 - studia doktoranckie

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Rada Dyscypliny Nauki medyczne


Hołda, Mateusz

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pol; eng

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tylko w bibliotece

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Last modified:

Jun 4, 2024

In our library since:

Apr 26, 2024

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ZB-140090 Jun 4, 2024


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