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Title: Clinico-morphological analysis of sporadic and syndromic odontogenic keratocysts of the jaws
Abstract:
Odontogenic keratocyst (OKC) is a histologically benign lesion with a tendency to infiltrative growth and a relatively high risk of recurrence. The aim of the study was a comparative assessment of clinical, radiological and morphological features, expression level of RANK, RANKL, OPG, COX-2, markers of apoptosis and cell proliferation in sporadic and syndromic forms of OKC and their relationship with recurrence. The sporadic forms of OKC do not show significant differences from the syndromic forms in terms of the assessed features, with the exception of the patient's age at diagnosis, which is significantly lower in the case of the syndromic forms. The recurrence rate of syndromic OKC is more than nine times higher than that of sporadic. Syndromic OKCs show significantly higher expression levels of PCNA, p53 and OPG than sporadic. The size and radiological presence of cortical bone perforations increase the risk of recurrence of sporadic OKCs approximately sevenfold. None of the assessed clinical, radiological and morphological features significantly increased the risk of recurrence of syndromic forms of OKC. Recurrent sporadic OKCs significantly differ from non-recurrent in the level of COX-2 expression, however, this marker has not been shown to be of prognostic significance. The recurrent syndromic OKCs significantly differ from the non-recurrent in the ratio of RANKL to O ; PG, however, in the study sample, it was not possible to determine the prognostic significance of this factor.
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Rada Dyscypliny Nauki medyczne
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Last modified:
Apr 23, 2024
In our library since:
Apr 23, 2024
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http://dl.cm-uj.krakow.pl:8080/publication/5087
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| Edition name | Date |
|---|---|
| ZB-139443 | Apr 23, 2024 |
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