Association between Toll-like receptor 4-mediated inflammatory response and outcome after ischemic stroke - Digital Medical Library

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Title: Association between Toll-like receptor 4-mediated inflammatory response and outcome after ischemic stroke

Author:

Klimiec-Moskal, Elżbieta

Date:

Type:

Praca doktorska

Abstract:

Toll-like receptors 4 (TLR4) are pattern recognition receptors, which the main agonist is bacterial endotoxin (LPS). Expression of TLR4 on monocytes increases during ischemic stroke and correlates with poor functional outcome. Studies aimed to investigate the relationship between selected markers of immune response mediated by TLR4 and outcome after stroke. It was shown that higher level of proteins modulating the interaction between LPS and TLR4 (LBP and sCD14) is associated with higher mortality after stroke. Results suggest that decreased release of IP-10, TNFa, IL-1b and IL-12, and increased release of IL-10 and IL-8 after whole blood stimulation with LPS are related to poor stroke outcome. In addition, multimarker score based on IL-12, IL-10 and TNFa levels after LPS stimulation and plasma IL-6 level improves the prognostic value of the clinical model for predicting stroke outcome.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Dziedzic, Tomasz

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:5083

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

ischemic stroke outcome inflammation endotoxin cytokines

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Apr 15, 2024

In our library since:

Apr 15, 2024

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0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5084

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Edition name	Date
ZB-132352	Apr 15, 2024

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