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This publication is protected and can be accessed only from certain IPs.

Title: Modification of selected parameters of the immune response in patients with connective tissue diseases under the influence of treatment with hydroxychloroquine


Objective: The aim of this study was to evaluate the effect of hydroxychloroquine on the modification of selected immunological parameters in patients with connective tissue diseases. Materiał and methods: Laboratory tests were collected and clinical data analyzed to evaluate potentia! risk factors for the development of interstitial Jung disease (ILD) as well as for autoimmune liver disease and vaccine response in patients under the influence of hydroxychloroquine. Results: Patients with pulmonary fibrosis had a !ower PFT value and an abnormal 6 MWT result. Hand edema, sclerodactyly, and the presence of megacapillaries correlated with the risk of developing interstitial lung disease. Patients with detected AMA showed significantly higher ALP and GGTP values compared to patients with SCLE without AMA and higher levels of immunoglobulin M compared to those with and without SCLE. The activity of liver enzymes increased significantly only in the group of patients with SCLE and AMA. Six weeks after vaccination, patients with OLE had at least a 2- fold increase in anti-PCP antibodies in the IgM and IgG classes compared to the pre-vaccination level. Conclusions: The presence of megacapillaries may be considered a prognostic marker for the development of interstitial lung disease in patients with short disease duration. Patients with ne ; wly diagnosed SCLE should be screened for AMA and should avoid potentially hepatotoxic drugs, including hydroxychloroquine. Vaccination of CLE patients treated with hydroxycholoroquine is safe, and the introduced therapy does not affect the vaccine response compared to the control group.

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Level of degree:

2 - studia doktoranckie

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Rada Dyscypliny Nauki medyczne


Wojas-Pelc, Anna

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pol; eng

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tylko w bibliotece

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Mar 25, 2024

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Feb 6, 2024

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ZB-136741 Mar 25, 2024


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