Object

Title: Association between cerebral and supraaortic arteries flow parameters and cognitive impairment in patients with aortic stenosis

Abstract:

The results of Phd dissertation are presented in peer-reviewed publications. The aim was to assess the potential correlation between degenerative aortic stenosis (DAS) severity, the intracranial and supraartic arterial flow parameters and the cognitive function. Additionally, the evaluation of the novel cardio-vascular and laboratory parameters potentially associated with prognosis in DAS patients were obtained. According to results, following conclusions were drawn: -Cerebral flow parameters were significantly lower in DAS patients vs without aortic stenosis -Cognitive impairment mostly depends on concomitant cardiovascular risk factor rather than DAS severity -The prevalence of elevated vascular stiffness is higher in DAS patients in comparison to the patients with cardiovascular risk factors without DAS -Elevated vascular resistance parameters of supraaortic arteries were an independent risk factor of cardiovascular events -In patients who underwent intervention for DAS, those with high vascular stiffness, presented more frequent cardiovascular events -Cytokines involved in calcification and osteogenesis process, correlate with DAS severity as well as prognosis -Parameters referred to left ventricle injury as DAS consequence (ET1, hs-TnT) are combined with cardiovascular death -Vascular stiffness parameters, female gender and Gal-3 se ; rum concentration were associated with heart failure episodes

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Kabłak-Ziembicka, Anna ; Podolec, Jakub

Date issued:

2022

Identifier:

oai:dl.cm-uj.krakow.pl:5020

Call number:

ZB-136745

Language:

pol; eng

Access rights:

nieograniczony

Object collections:

Last modified:

Mar 21, 2024

In our library since:

Feb 6, 2024

Number of object content hits:

45

Number of object content views in PDF format

20

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5021

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ZB-136745 Mar 21, 2024
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