Advanced search ?

Object

Access Limited

This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Selenium as an element of dietary habits in the etiology and clinical consequences of colorectal cancer

Author:

Augustyniak, Małgorzata

Date:

2023

Type:

Praca doktorska

Abstract:

Selenium due to its antioxidant function can prevent cancers, including colorectal cancer. Despite the knowledge about the pathophysiological protective mechanisms of selenium in colorectal cancer, the results of studies are inconclusive, indicating the need for further research on the role of selenium in colorectal cancer. The work revealed that selenium reduced the risk of colorectal cancer by 8%, with an increase in intake by every 10 μg. Furthermore, the effect of selenium was modified by calcium. In subjects with lower calcium intake (<1000 mg/day) the risk of colorectal cancer was reduced by 13%, and by 44% and 66% - depending on the assigned category of selenium dietary intake: 60 to <80 μg/day and ≥80 μg/day. In the presented work the effect of selenium intake on the survival of patients with colorectal cancer referred to surgery was also investigated. Using the Cox regression model, after standardization, it was observed that subjects in the group with higher dietary selenium intake (≥48.8 μg/day) had 27% lower risk of dying from colorectal cancer compared to those in the group with lower dietary selenium intake (<48.8 μg/day) (HR=0.73; 95%CI: 0.54-0.98). It was observed that increased selenium intake in a population with a low selenium intake may bring beneficial effects in prevention and in long-term clinical effects.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Gałaś, Aleksander

Date issued:

2023

Identifier:

oai:dl.cm-uj.krakow.pl:5010

Call number:

ZB-138362

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

selenium intake calcium intake colorectal cancer modification effect survival

Object collections:

Last modified:

Mar 22, 2024

In our library since:

Jan 10, 2024

Number of object content hits:

0

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5011

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-138362 Mar 22, 2024

Objects

Similar

Selenium as an element of dietary habits in the etiology and clinical consequences of colorectal cancer

Augustyniak, Małgorzata

2023
Praca doktorska

Retrospective analysis of colorectal cancer screening colonoscopies

Matyja, Maciej

2018
Praca doktorska

Psychosocial determinants of illness behaviours : date among patients with colorectal cancer

Kamińska, Alicja

2007
Praca doktorska

Evaluation of the results of treatment of ovarian cancer in Gynecology and Oncology Clinic Jagiellonian University Collegium Medicum in Cracow in 1998-2006

Mika, Marcin

2013
Praca doktorska

Ghrelin level in plasma of healhy group and in patients with colorectal cancer

Kenig, Jakub

2008
Praca doktorska

The use of selected laboratory and clinical parameters in predictingprognosis and treatment efficacy in patients with acute myeloidleukemia

Raźny, Małgorzata

2014
Praca doktorska

The role of diet in the etiology of colorectal cancer

Komisarska, Renata

2005
Praca doktorska

Low-level instability of microsatellite DNA in sporadic colorectal cancers

Klimkowska, Agnieszka

2011
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information