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Title: Study of the effect of hypertension and age on the formation of hydrogen sulfide and nitric oxide in selected rat tissues


Hypertension is considered a civilization disease of the 21st century, and its incidence increases with age. Hydrogen sulfide (H2S) and nitric oxide (NO) play an important role in the vasodilation process. The aim of the study was to investigate the effect of hypertension and age on the H2S formation, the expression and activity of sulfur enzymes, the level of low molecular sulfur-containing compounds and the NO level in rat tissues, as well as the level of endogenous metabolites related to NO biosynthesis (in plasma and urine). The research material consisted of tissues (livers, hearts, kidneys), plasma, and urine of 16- and 60-week-old normotensive and 16- and 60-week-old spontaneously hypertensive rats. The experiments included the study of the ability of tissues to generate H2S, the study of the expression of sulfur enzyme genes (CBS, CTH, MPST, TST) at the mRNA level and the determination of the activity of these enzymes, the study of the level of sulfane sulfur and low molecular sulfur-containing compounds, as well as the determination of the NO level, the study of eNOS gene expression in tissues and the determination of the level of NO-related metabolites. It was shown that arterial hypertension and the age of animals affect the ability of rat tissues to form H2S and the transformation of sulfur compounds, and the occurring changes depend on the type of tissue. Hypertens ; ion and the age of the animals also affect tissue NO levels and the nitrogen compounds metabolism in rats. There is a positive dependence between endogenous levels of H2S and NO in the hearts and kidneys of normotensive or hypertensive rats of different ages.

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2 - studia doktoranckie

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Rada Dyscypliny Nauki medyczne


Wróbel, Maria ; Ufnal, Marcin

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pol; eng

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tylko w bibliotece

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Jan 10, 2024

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Jan 10, 2024

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ZB-138273 Jan 10, 2024


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