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Title: The role of the CD36 and SR-A / CD204 scavenger receptors in the fight against bacterial infections

Author:

Domagała, Angelika

Date:

2023

Type:

Praca doktorska

Abstract:

Opsonin-independent macrophage scavenger-mediated macrophagemediated phagocytosis is an early mechanism of host antimicrobial defense. The ability to bind bacteria is common to all types of SR. Most studies have used fluorescently labeled surface altered bacteria. In addition, the increased susceptibility to Staphylococcus aureus (Sa) infections in SR-A / CD204- or CD36-deficient mice was attributed to macrophage-mediated impairment of phagocytosis, which, however, contradicts the low efficacy of unopsonized Sa phagocytosis in macrophages. In our study, we observed that, unlike the phagocytosis of killed and fluorescently labeled bacteria used in previous experiments, phagocytosis of non-opsonized live bacteria is less efficient and not impaired in CD36 or SR-A / CD204 deficient macrophages. Our results also show that the SR-A / CD204 and CD36 receptors influence Sa-stimulated cytokine production in murine macrophages differently depending on the dose of the bacteria. Acting as coreceptors and regulators of endocytosis, CD36 and SR-A enable intracellular activation of the Toll-like receptor 2 (TLR2) by lower doses of bacteria. However, at higher doses of bacteria, the participation of both receptors in TLR2 activation becomes redundant and their inhibitory effect on cytokine production begins to prevail.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Józefowski, Szczepan

Date issued:

2022

Identifier:

oai:dl.cm-uj.krakow.pl:5000

Call number:

ZB-136746

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

scavenger receptors Toll-like receptor 2 Staphylococcus aureus cytokine phagocytosis

Object collections:

Last modified:

Nov 28, 2023

In our library since:

Nov 28, 2023

Number of object content hits:

0

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5001

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Edition name Date
ZB-136746 Nov 28, 2023

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