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This publication is protected and can be accessed only from certain IPs.

Title: The genetic background of the pathogenesis of the lumbar intervertebral discs degenerative disease

Author:

Pękala, Przemysław Andrzej

Date:

2023

Type:

Praca doktorska

Abstract:

Intervertebral disc degeneration is a multifaceted pathology that is the main morphological cause of lower back pain, which affects approximately 80% of the generał population. The age of the symptoms onset ranges from 20 to 50 years, which coincide with the highest socio-economic activity. Due to utilization of the interdisciplinary methods such as evidence-based medicine tools, anatomie dissection with morphological assessment (including histological methods), radiological imaging (MRI), and molecular biology techniques it was possible to obtain high quality results. The gathered data may have broad practical implications as a part of scientific evidence on genetics behind the development of the lumbar spine degeneration and influence the interpretation of the radiologi cal studies. Nonetheless, to fully understand multigenic and pleiotropic relationships between the genotype and the phenotype (including the intervertebral disc disease pathogenesis) future well designed and high quality studies are required to be performed on numerous populations.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

anatomia ; choroby narządów ruchu

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Tomaszewski, Krzysztof

Date issued:

2022

Identifier:

oai:dl.cm-uj.krakow.pl:4970

Call number:

ZB-136287

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

morphology clinical anatomy genetics low back pain

Object collections:

Last modified:

Mar 22, 2024

In our library since:

Mar 8, 2023

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4971

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Edition name Date
ZB-136287 Mar 22, 2024

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