Object
Title: Hypertension in prematurely born children and children born on time
Abstract:
The dissertation presents the results of two prospective clinical trials analyzing the impact of prematurity on the blood pressure profile in children. The first study analyzes the blood pressure profile in a cohort of former preterms at 7 and then at 11 years. Assessment at 7th year indicated more frequent occurrence of hypertension (HT), no normal nocturnal pressure drop, and an increased heart rate in the group of premature children. The evaluation at 11th year indicated the possibility of decreasing blood pressure in prematurely born children to a level that does not threaten organ damage. Unfortunately, the elevated heart rate maintained in this group of children, regardless of the treatment used. In the next stage, a single cases meta-analysis was carried out in cooperation with researchers from the University of Leuven. Cardiovascular and renal parameter collected at 11th year of life in both centers were combined into a common database, which allowed to confirm the previously collected results on a larger group and to analyze the function of kidneys in former preterms more accurately. The second study was a detailed analysis of the pressure profile and kidney function in even younger children. The aim was to understand the sequence of events leading to the development of HT in this group of patients. We have shown that children born prematurely at their expected deliver ; y date have elevated level of tubular damage markers, higher heart rate and lower total body water. This may predispose premature children to develop HT and worsen their kidney function later in life.
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Rada Dyscypliny Nauki medyczne
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Last modified:
Mar 22, 2024
In our library since:
Mar 1, 2023
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http://dl.cm-uj.krakow.pl:8080/publication/4954
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| Edition name | Date |
|---|---|
| ZB-136084 | Mar 22, 2024 |
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