Novel markers of renal impairment in multiple myeloma patients - Digital Medical Library

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Title: Novel markers of renal impairment in multiple myeloma patients

Author:

Woziwodzka, Karolina

Date:

Type:

Praca doktorska

Abstract:

Renal impairment (RI) in multiple myeloma (MM) affects 50% patients, leads to increased morbidity. The aim of this study was to evaluate the utility of markers: IGFBP-7, TIMP-2, transgelin-2 and monomer NGAL in MM, the influence of neoplasm on their concentrations and interactions between them. The follow-up data included serum creatinine, eGFR, the date and cause of death. Elevated serum and urine levels of these biomarkers were observed. The urine concentration of monomer NGAL, IGFBP-7 and serum concentration of transgelin-2 correlated with the decrease of eGFR and higher disease stage. They may be considered predicative of future chronic kidney disease. Majority of tubular biomarkers correlate with one another; however transgelin-2 seems to be an independent marker. The early measurement of these biomarkers in MM patients allows to predict the development of chronic kidney injury. The idea of creation of biomarkers panels seems to be superior in future development of their use.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia ; nefrologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Krzanowska, Katarzyna

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4951

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

multiple myeloma renal impairment tubular markers of kidney injury

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Mar 25, 2024

In our library since:

Feb 28, 2023

Number of object content hits:

5

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4952

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Edition name	Date
ZB-136329	Mar 25, 2024

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