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Title: Disorders of thyroid function and morphology in children and adolescents after biological treatment

Author:

Furtak, Aleksandra

Date:

2022

Type:

Praca doktorska

Abstract:

Biological drugs are one of the greatest innovations in the medicine. Despite their increasing use in the pediatric population, there is insufficient knowledge about their influence on the function and morphology of the thyroid gland, the dysfunction of which is the most common endocrinopathy in childhood. For example, the literature data on the effect of the very commonly used anti-TNF-alpha (anti-tumor necrosis factoralpha) therapy on thyroid function is very diverse and concerns mainly the adult patient population. The own studies assessed the function and morphology of the thyroid gland in pediatric patients treated with anti-TNF-alpha for Crohn's disease and in patients treated with enzyme replacement therapy for storage diseases. The results indicate the preventive role of anti-TNFalpha therapy in the development of thyroid gland disorders and the high usefulness of thyroid ultrasound examination as a tool in identifying patients at risk of developing thyroid disorders. In the group of patients with storage diseases, the results indicate that the use of enzyme replacement therapy may have a protective effect against the accumulation of non-metabolized substances in the thyroid gland and thus prevent disturbances in the function and morphology of this gland.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; pediatria

Degree grantor:

Wydział Lekarski

Promoter:

Wędrychowicz, Anna

Date issued:

2022

Identifier:

oai:dl.cm-uj.krakow.pl:4942

Call number:

ZB-136290

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

biological treatment enzyme replacement therapy thyroid dysfunction autoimmune thyroid disease ultrasound of the thyroid gland

Object collections:

Last modified:

Apr 8, 2024

In our library since:

Feb 27, 2023

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Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4943

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Edition name Date
ZB-136290 Apr 8, 2024

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