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neuropathic pain ; chemotherapy-induced peripheral neuropathy ; oxaliplatin ; thermal preference test ; mice
Abstract:
This doctoral thesis allows selection of drugs and chemical compounds with the potential efficacy in alleviating symptoms and preventive effect - inhibiting the development of pain symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in mice. As this disease affects an increasing number of patients, and the etiopathogenesis and symptoms are partially similar in rodents and humans, preclinical studies are an important source of information and an introduction to clinical trials. For most compounds, it was possible to determine the effective and subliminal dose. Additionally, the use of combination drug treatment associated with a time interval showed an interesting profile of analgesic activity in some of the connections. By repeated administration of drugs, a protective effect has been shown - inhibiting the development of late hypersensitivity to oxaliplatin. The use of a prevention protocol made it possible to assess the potential protective effect of drugs on the development of the CIPN model. Particular attention should be paid to duloxetine, which has already been shown to be active after a single administration and ambroxol, which, administered once, inhibited the development of hypersensitivity to thermal and mechanical stimuli. Employment of new experimental equipment in the last stage of the research allowed to evaluate the temper ; ature preferences of animals depending on the temperature of the plates and administered drugs. The innovative approach and the use of computer methods have improved the acquisition and interpretation of results. This last step of the study allowed for a more accurate evaluation of the pharmacological activity of duloxetine and pregabalin in terms of their analgesic effect in an oxaliplatin-induced CIPN animal model.
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Rada Dyscypliny Nauki farmaceutyczne