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Title: The impact of the technological modifications on the liquisolid tablets quality
Abstract:
In modern pharmaceutical technology, the development of solid oral dosage forms is still of particular interest for many research centers, especially in terms of poorly water-soluble drugs dosage form development. In this dissertation, the research focused on the design of liquisolid tablets containing furosemide as a model drug, development of their preparation technology, evaluation of physical properties, dissolution, and stability. Among the used solvents, macrogol 400 was identified to be the best. Nine placebo tablet batches and 26 batches of tablets with furosemide were prepared. Based on the tablets composition was selected for the preparation of powder mixtures with the use of high-shear and fluid-bed granulators. In the case of the high-shear granulator, it was necessary to modify the spraying system. High-shear granulation was selected for the final formulation, based on the obtained results. In order to reduce the weight of the tablets, the liquid fraction was alkalized, which resulted in an increase of furosemide concentration up to 30%. Tablets packed in PVC/Alu blisters were stored in climate chambers for 12 months and at room temperature for 24 months retained unchanged properties. The proposed technology of applying the liquid fraction to excipients using a high-shear granulator with a modified spraying system allowed for trouble-free compression of the tabl ; et mass and obtaining liquisolid tablets which meet the pharmacopeial requirements. The prepared tablets also showed a better furosemide release profile comparison with the reference drug.
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Rada Dyscypliny Nauki farmaceutyczne
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Last modified:
Mar 22, 2024
In our library since:
Jan 24, 2023
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1
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0
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http://dl.cm-uj.krakow.pl:8080/publication/4927
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| Edition name | Date |
|---|---|
| ZB-135521 | Mar 22, 2024 |
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