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Title: Analysis of the effects of a novel neuropeptide – kisspeptin –on peripheral and central mechanisms of metabolic dysfunction in an animal model of activity-based anorexia

Author:

Skowron, Kamil

Date:

2022

Type:

Praca doktorska

Abstract:

The modern model explaining the onset and development of anorexia nervosa (AN) recognizes a distinct dysfunction in metabolic pathways that induce or at least potentiate multisystemic clinical symptoms. The main objective of this study was to explore the neurobiological basis of AN by assessing the effect of exogenous kisspeptin on the development and course of abnormalities observed in an animal model of activity-based anorexia (ABA). Peripheral and central neurohormonal disturbances of the ABA model were analyzed. Using magnetic resonance spectroscopy, a neurochemical profile of the hypothalamus and brainstem of the animals studied was developed. The obtained spectra of brain metabolites showed an imbalance reflecting the effects of ABA on local energy balance and adaptive antioxidant mechanisms. Kisspeptin administered subcutaneously alleviated ABA modeling by altering the pattern of weight loss. In addition, partial normalization of GABA and creatine levels (hypothalamus) as well as restoration of basal glutamate levels (brainstem) was achieved in brain centers responsible for the regulation of appetite and satiety. The results obtained indicate that kisspeptin potentially through modulation of hypothalamic GABA-ergic signaling increases food intake and thus positively affects brain metabolism.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

patofizjologia

Degree grantor:

Wydział Lekarski

Promoter:

Gil, Krzysztof ; Kurnik-Łucka, Magdalena

Date issued:

2022

Identifier:

oai:dl.cm-uj.krakow.pl:4911

Call number:

ZB-135517

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

anorexia nervosa activity-based anorexia kisspeptin neurochemical profile hypothalamus

Object collections:

Last modified:

May 17, 2023

In our library since:

Dec 17, 2022

Number of object content hits:

5

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4912

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Edition name Date
ZB-135517 May 17, 2023

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