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This publication is protected and can be accessed only from certain IPs.

Title: Evaluation of selected proinflammatory cytokines in psoriatic and psoriatic arthritis patients with coexisting metabolic syndrome

Abstract:

INTRODUCTION: Psoriasis is a common chronic skin disease. In recent years, research has shown the association of dermatosis with numerous accompanying diseases, most often with cardiovascular diseases and metabolic syndrome, determining psoriasis as a predisposing factor. OBJECTIVE: The aim of this dissertation was to evaluate the epidemiology of patients with psoriasis and psoriatic arthritis and to study the levels of TNF-α, IL-12, IL-23 and IL-17 in patients’ blood in correlation with individual components of the metabolic syndrome. MATERIAL AND METHODS: A retrospective study evaluated data from 3,331 hospitalizations and 1,537 outpatient cards of patients with psoriasis. For the study of cytokines 60 patients with severe psoriasis were included. Control groups were: 15 subjects diagnosed with metabolic syndrome and 15 healthy voluntary subjects. The concentrations of IL-12, IL-17, IL-23 and TNF-α in serum were determined. RESULTS: The level of the studied cytokines: IL-23 and TNF-α was higher in patients diagnosed with psoriasis in comparison to the control group. Higher levels of IL-17 were observed in patients with metabolic syndrome associated with psoriasis. The level of cytokines was also assessed in relation to the presence of specific co-morbidities that are components of the metabolic syndrome. The level of IL-17 was higher in the group of patients diagnosed wit ; h diabetes mellitus and dislipidemia. In the study, a higher level of IL-17 and IL-23 was also shown, in patients with psoriatic arthritis in comparison to patients with normal psoriasis. CONCLUSIONS: It seems very important to study immunologic mechanisms responsible for the presence of psoriasis to personalize the therapy and optimize the effect of action on the basic disease and on concomitant disorders.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

dermatologia

Degree grantor:

Wydział Lekarski

Promoter:

Wojas-Pelc, Anna

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4772

Call number:

ZB-130876

Language:

pol; eng

Access rights:

tylko w bibliotece

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Last modified:

Jul 6, 2022

In our library since:

Jul 6, 2022

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http://dl.cm-uj.krakow.pl:8080/publication/4773

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ZB-130876 Jul 6, 2022
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