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Title: Selected inflammatory markers and antibodies against heat shock protein 60 in women taking estrogentherapy


Background: The theories formulated to explain atherogenesis have been evolving from vessel wall lipid accumulation to endothelial dysfunction with vascular wall remodeling. The progress in basic and experimental science have shown that inflammatory and immunological processes, cell and molecular mechanism can initiate atherogenesis. The clinical observation of those changes in postmenopausal women has important meaning. Aim: The influence of three different forms estrogenprogestin therapy on the bahaviour of antibodies against heat shock protein 60and selected inflammatory markers in healthy postmenopausal women. Material and methods: The study was carried out with 60 women hospitalized or treated in the outpatient clinic at the Endocrinological Gynecology Department, Jagiellonian University between 2004 and 2008. All the patients were in menopausal age (51 +/- 3 years ), with FSH levels above 25 mIU/ml, with menopausal symptoms disturbing normal daily activity, and they all fulfilled criteria for hormonal therapy specified by the Standards of Polish Gynecological Society. The study was done for the period of 6 months. Conclusions: In own data statistically significant decrease of fibrinogen, ICAM-1, VCAM-1 and antibodies against HSP 60 were demonstrated in all treated groups vs control group. The way of estrogen administration, its dose and used gesta ; gen have not differed the examined groups. In control group and in oral estrogen-progestin therapy schema group the increase of hsCRP was observed. The transdermal estrogen therapy reduce the level of those acute phase protein.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

ginekologia ; farmakologia

Degree grantor:

Wydział Lekarski


Krzysiek, Józef

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tylko w bibliotece

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Last modified:

Jun 22, 2022

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Jun 22, 2022

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Edition name Date
ZB-113522 Jun 22, 2022


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