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Title: Genetic variability of cyclooxygenase-2 in coronary artery disease
Abstract:
The aim of the study was to evaluate: the allelic frequencies of two SNPs (G-765C and T8473C) of the COX-2 in pts with CAD and in subjects without symptoms of CAD; the association between SNPs and the age of the onset of symptoms and clinical presentation of CAD, the coronary findings, the type of treatment of CAD; the risk of myocardial infarction (MI) and stroke, the incidence of atherosclerotic risk factors; the influence of SNPs on the immediate and late outcomes after single-vessel PCI. The study comprised 256 subjects, including 186 CAD pts and 70 persons without symptoms of CAD. CAD pts were divided into: group A - 123 pts with stable CAD, aged 39-86 yrs (mean 62.6±11.2) including 37 (30.1%) women and group B - 63 pts with unstable angina (UA), aged 43-86 yrs (mean 64.0±10.8) including 12 (19.0%) women. There were no significant differences in -765C and 8473C allele frequencies between CAD pts and persons without symptoms of CAD. G-765C and T8473C SNPs had no significant association with the age of the onset of symptoms of CAD, previous MI and stroke, severity of coronary lesions, and with the type of CAD treatment. -765C-765G genotype was found significantly more often in stable CAD pts. 8473C8473C genotype was present more frequently in UA pts, whereas 8473C8473T genotype was found more often in stable CAD pts. In UA pts there was a significant association between G-76 ; 5C SNP and the occurrence of obesity and BMI value. In UA pts the highest HDL cholesterol level was found in -8473C-8473C homozygotes. During 36 months of follow-up, the carriers of the -765C allele with stable CAD had a MI significantly more often than -765G-765G homozygotes.
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Last modified:
Mar 15, 2023
In our library since:
Jun 22, 2022
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http://dl.cm-uj.krakow.pl:8080/publication/4747
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| Edition name | Date |
|---|---|
| ZB-114726 | Mar 15, 2023 |
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