The aims of the thesis were to assess the relationship between the strategy of coping with stress and the clinical condition of patients with RA, and to assess the relationship between the plasma concentration of selected hormones and the clinical condition of these patients. Three methods of data collection were used in the study: 1) questionnaire survey: Inventory for Measuring Coping with Stress (Mini-COPE), the Perceived Stress Scale (PSS-10) and the Life Events Questionnaire (KWŻ). 2) biochemical tests, where the concentrations of cortisol, serotonin and melatonin in the blood plasma were determined. 3) and data form patients' medical records (DAS28 index and the concentration of C-reactive protein). Patients with RA experienced the intensity of stress at a similar level as in the control group. Patients with low or moderate DAS28 index experienced a lower intensity of stress compared to patients with high index. The most frequently used strategies for coping with stress were: ‘active coping’, ‘planning’ and ‘acceptance’, however, when the disease exacerbated, they used the ‘denial’ strategy more often. Patients with RA were characterized by a higher concentration of cortisol and serotonin and a lower concentration of melatonin in the blood plasma compared to the control group. Melatonin and cortisol levels varied depending on the disease activity index, while serotonin le ; vels were at a comparable level.
Jaworek, Jolanta ; Szklarczyk, Joanna
Mar 17, 2023
May 23, 2022
|ZB-134973||Mar 17, 2023|