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Title: Metabolism of angiotensins in human placenta in preeclampsia

Author:

Stettner-Kołodziejska, Dominika

Type:

Praca doktorska

Abstract:

The aim of the paper was to examine the metabolism of angiotensin I, to compare the production of Ang I metabolites and to assess the expression of enzymes/receptors in the placenta in physiological and complicated by preeclampsia pregnancy in an ex vivo model. Patients were divided into 2 groups (n=14 in each group): a study group and a control (comparative) group. Placental samples were taken directly after omphalotomy and transported in order to be prepared for testing (LC-MS- liquid chromatography-mass-spectrometry, RT-PCR). It was the first time the LC-MS technique was used to assess the ability of placental tissue to convert Ang I. Efficient metabolism of Ang I to angiotensin peptides was demonstrated, confirming efficient functioning of RAS in the placenta. The primary metabolite of Ang I in both groups was Ang-(1-7). Lower RAS activity, decreased expression of ACE and decreased expression of the Ang II receptor was found in patients from the study group. It was also confirmed that ACE is the enzyme responsible for the production of Ang II to the greatest extent. There are reports of both increased and decreased expression of AT1R, as well as of no differences observed. The discrepancies in certain results of this study relative to data found in literature may stem from the use of different methods and certainly call for further research.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

stan przedrzucawkowy

Degree grantor:

Wydział Lekarski

Promoter:

Rytlewski, Krzysztof

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4705

Call number:

ZB-130757

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

renin-angiotensin system; preeclampsia

Object collections:

Last modified:

Jun 26, 2023

In our library since:

May 23, 2022

Number of object content hits:

6

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4706

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Edition name Date
ZB-130757 Jun 26, 2023

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